| Saturday, 12/04/1980 | Caulfield City - Brighton | 0:2 | ||||||
| Saturday, 12/04/1980 | Corio - Moorabbin City | 0:0 | ||||||
| Saturday, 12/04/1980 | Keysborough - Sandringham City | 0:2 | ||||||
| Saturday, 12/04/1980 | Mooroolbark - North Dandenong | 1:1 | ||||||
| Saturday, 12/04/1980 | Mornington - Werribee City | 1:0 | ||||||
| Saturday, 12/04/1980 | Nunawading City - Monash University | 1:2 |
| Saturday, 19/04/1980 | Brighton - Mooroolbark | 1:1 | ||||||
| Saturday, 19/04/1980 | Monash University - Keysborough | 0:1 | ||||||
| Saturday, 19/04/1980 | Moorabbin City - Nunawading City | 2:2 | ||||||
| Saturday, 19/04/1980 | North Dandenong - Corio | 1:0 | ||||||
| Saturday, 19/04/1980 | Sandringham City - Mornington | 0:1 | ||||||
| Saturday, 19/04/1980 | Werribee City - Caulfield City | 4:0 |
| Saturday, 26/04/1980 | Caulfield City - Sandringham City | 1:3 | ||||||
| Saturday, 26/04/1980 | Corio - Brighton | 1:0 | ||||||
| Saturday, 26/04/1980 | Moorabbin City - Monash University | 3:2 | ||||||
| Saturday, 26/04/1980 | Mooroolbark - Werribee City | 0:2 | ||||||
| Saturday, 26/04/1980 | Mornington - Keysborough | 1:1 | ||||||
| Saturday, 26/04/1980 | Nunawading City - North Dandenong | 0:1 |
| Saturday, 03/05/1980 | Brighton - Nunawading City | 1:3 | ||||||
| Saturday, 03/05/1980 | Keysborough - Caulfield City | 2:1 | ||||||
| Saturday, 03/05/1980 | Monash University - Mornington | 1:4 | ||||||
| Saturday, 03/05/1980 | North Dandenong - Moorabbin City | 3:0 | ||||||
| Saturday, 03/05/1980 | Sandringham City - Mooroolbark | 2:1 | ||||||
| Saturday, 03/05/1980 | Werribee City - Corio | 0:2 |
| Saturday, 10/05/1980 | Caulfield City - Mornington | 0:4 | ||||||
| Saturday, 10/05/1980 | Corio - Sandringham City | 1:2 | ||||||
| Saturday, 10/05/1980 | Moorabbin City - Brighton | 5:1 | ||||||
| Saturday, 10/05/1980 | Mooroolbark - Keysborough | 1:2 | ||||||
| Saturday, 10/05/1980 | North Dandenong - Monash University | 0:0 | ||||||
| Saturday, 10/05/1980 | Nunawading City - Werribee City | 2:3 |
| Saturday, 17/05/1980 | Brighton - North Dandenong | 3:3 | ||||||
| Saturday, 17/05/1980 | Keysborough - Corio | 0:2 | ||||||
| Saturday, 17/05/1980 | Monash University - Caulfield City | 1:0 | ||||||
| Saturday, 17/05/1980 | Mornington - Mooroolbark | 2:0 | ||||||
| Saturday, 17/05/1980 | Sandringham City - Nunawading City | 2:0 | ||||||
| Saturday, 17/05/1980 | Werribee City - Moorabbin City | 5:0 |
| Saturday, 24/05/1980 | Brighton - Monash University | 2:1 | ||||||
| Saturday, 24/05/1980 | Corio - Mornington | 1:1 | ||||||
| Saturday, 24/05/1980 | Moorabbin City - Sandringham City | 2:1 | ||||||
| Saturday, 24/05/1980 | Mooroolbark - Caulfield City | 2:0 | ||||||
| Saturday, 24/05/1980 | North Dandenong - Werribee City | 1:1 | ||||||
| Saturday, 24/05/1980 | Nunawading City - Keysborough | 2:1 |
| Saturday, 31/05/1980 | Caulfield City - Corio | 0:1 | ||||||
| Saturday, 31/05/1980 | Keysborough - Moorabbin City | 2:2 | ||||||
| Saturday, 31/05/1980 | Monash University - Mooroolbark | 2:1 | ||||||
| Saturday, 31/05/1980 | Mornington - Nunawading City | 2:1 | ||||||
| Saturday, 31/05/1980 | Sandringham City - North Dandenong | 2:2 | ||||||
| Saturday, 31/05/1980 | Werribee City - Brighton | 2:1 |
| Saturday, 07/06/1980 | Brighton - Sandringham City | 4:1 | ||||||
| Saturday, 07/06/1980 | Corio - Mooroolbark | 2:1 | ||||||
| Saturday, 07/06/1980 | Moorabbin City - Mornington | 2:2 | ||||||
| Saturday, 07/06/1980 | North Dandenong - Keysborough | 1:1 | ||||||
| Saturday, 07/06/1980 | Nunawading City - Caulfield City | 4:0 | ||||||
| Saturday, 07/06/1980 | Werribee City - Monash University | 2:3 |
| Saturday, 14/06/1980 | Caulfield City - Moorabbin City | 0:3 | ||||||
| Saturday, 14/06/1980 | Keysborough - Brighton | 1:3 | ||||||
| Saturday, 14/06/1980 | Monash University - Corio | 2:1 | ||||||
| Saturday, 14/06/1980 | Mornington - North Dandenong | 2:0 | ||||||
| Saturday, 14/06/1980 | Nunawading City - Mooroolbark | 1:0 | ||||||
| Saturday, 14/06/1980 | Sandringham City - Werribee City | 0:4 |
| Saturday, 21/06/1980 | Brighton - Mornington | 3:2 | ||||||
| Saturday, 21/06/1980 | Corio - Nunawading City | 1:1 | ||||||
| Saturday, 21/06/1980 | Monash University - Sandringham City | 1:1 | ||||||
| Saturday, 21/06/1980 | Moorabbin City - Mooroolbark | 2:3 | ||||||
| Saturday, 21/06/1980 | North Dandenong - Caulfield City | 4:1 | ||||||
| Saturday, 21/06/1980 | Werribee City - Keysborough | 2:0 |
| Saturday, 28/06/1980 | Brighton - Caulfield City | 5:1 | ||||||
| Saturday, 28/06/1980 | Moorabbin City - Corio | 0:0 | ||||||
| Saturday, 28/06/1980 | Sandringham City - Keysborough | 0:1 | ||||||
| Saturday, 28/06/1980 | North Dandenong - Mooroolbark | 4:0 | ||||||
| Saturday, 28/06/1980 | Werribee City - Mornington | 2:1 | ||||||
| Saturday, 28/06/1980 | Monash University - Nunawading City | 2:4 |
| Saturday, 05/07/1980 | Mooroolbark - Brighton | 1:2 | ||||||
| Saturday, 05/07/1980 | Keysborough - Monash University | 1:2 | ||||||
| Saturday, 05/07/1980 | Nunawading City - Moorabbin City | 5:1 | ||||||
| Saturday, 05/07/1980 | Corio - North Dandenong | 2:1 | ||||||
| Saturday, 05/07/1980 | Mornington - Sandringham City | 1:3 | ||||||
| Saturday, 05/07/1980 | Caulfield City - Werribee City | 1:4 |
| Saturday, 12/07/1980 | Sandringham City - Caulfield City | 1:2 | ||||||
| Saturday, 12/07/1980 | Brighton - Corio | 3:2 | ||||||
| Saturday, 12/07/1980 | Monash University - Moorabbin City | 4:0 | ||||||
| Saturday, 12/07/1980 | Werribee City - Mooroolbark | 4:2 | ||||||
| Saturday, 12/07/1980 | Keysborough - Mornington | 2:1 | ||||||
| Saturday, 12/07/1980 | North Dandenong - Nunawading City | 1:1 |
| Saturday, 19/07/1980 | Nunawading City - Brighton | 2:2 | ||||||
| Saturday, 19/07/1980 | Caulfield City - Keysborough | 1:1 | ||||||
| Saturday, 19/07/1980 | Mornington - Monash University | 1:0 | ||||||
| Saturday, 19/07/1980 | Moorabbin City - North Dandenong | 1:1 | ||||||
| Saturday, 19/07/1980 | Mooroolbark - Sandringham City | 2:4 | ||||||
| Saturday, 19/07/1980 | Corio - Werribee City | 0:1 |
| Saturday, 26/07/1980 | Mornington - Caulfield City | 4:0 | ||||||
| Saturday, 26/07/1980 | Sandringham City - Corio | 2:3 | ||||||
| Saturday, 26/07/1980 | Brighton - Moorabbin City | 3:1 | ||||||
| Saturday, 26/07/1980 | Keysborough - Mooroolbark | 0:1 | ||||||
| Saturday, 26/07/1980 | Monash University - North Dandenong | 5:0 | ||||||
| Saturday, 26/07/1980 | Werribee City - Nunawading City | 2:0 |
| Saturday, 02/08/1980 | North Dandenong - Brighton | 3:3 | ||||||
| Saturday, 02/08/1980 | Corio - Keysborough | 3:1 | ||||||
| Saturday, 02/08/1980 | Caulfield City - Monash University | 0:1 | ||||||
| Saturday, 02/08/1980 | Mooroolbark - Mornington | 1:1 | ||||||
| Saturday, 02/08/1980 | Nunawading City - Sandringham City | 3:0 | ||||||
| Saturday, 02/08/1980 | Moorabbin City - Werribee City | 1:5 |
| Saturday, 09/08/1980 | Monash University - Brighton | 2:1 | ||||||
| Saturday, 09/08/1980 | Mornington - Corio | 0:1 | ||||||
| Saturday, 09/08/1980 | Sandringham City - Moorabbin City | 2:2 | ||||||
| Saturday, 09/08/1980 | Caulfield City - Mooroolbark | 1:1 | ||||||
| Saturday, 09/08/1980 | Werribee City - North Dandenong | 2:0 | ||||||
| Saturday, 09/08/1980 | Keysborough - Nunawading City | 1:0 |
| Saturday, 16/08/1980 | Corio - Caulfield City | 1:0 | ||||||
| Saturday, 16/08/1980 | Moorabbin City - Keysborough | 1:0 | ||||||
| Saturday, 16/08/1980 | Mooroolbark - Monash University | 2:1 | ||||||
| Saturday, 16/08/1980 | Nunawading City - Mornington | 0:3 | ||||||
| Saturday, 16/08/1980 | North Dandenong - Sandringham City | 1:1 | ||||||
| Saturday, 16/08/1980 | Brighton - Werribee City | 1:1 |
| Saturday, 23/08/1980 | Sandringham City - Brighton | 1:4 | ||||||
| Saturday, 23/08/1980 | Mooroolbark - Corio | 0:2 | ||||||
| Saturday, 23/08/1980 | Mornington - Moorabbin City | 3:0 | ||||||
| Saturday, 23/08/1980 | Keysborough - North Dandenong | 1:1 | ||||||
| Saturday, 23/08/1980 | Caulfield City - Nunawading City | 0:2 | ||||||
| Saturday, 23/08/1980 | Monash University - Werribee City | 0:2 |
| Saturday, 30/08/1980 | Moorabbin City - Caulfield City | 3:0 | ||||||
| Saturday, 30/08/1980 | Brighton - Keysborough | 0:0 | ||||||
| Saturday, 30/08/1980 | Corio - Monash University | 6:1 | ||||||
| Saturday, 30/08/1980 | North Dandenong - Mornington | 1:1 | ||||||
| Saturday, 30/08/1980 | Mooroolbark - Nunawading City | 2:5 | ||||||
| Saturday, 30/08/1980 | Werribee City - Sandringham City | 2:0 |
| Saturday, 06/09/1980 | Mornington - Brighton | 1:0 | ||||||
| Saturday, 06/09/1980 | Nunawading City - Corio | 2:5 | ||||||
| Saturday, 06/09/1980 | Sandringham City - Monash University | 3:2 | ||||||
| Saturday, 06/09/1980 | Mooroolbark - Moorabbin City | 1:2 | ||||||
| Saturday, 06/09/1980 | Caulfield City - North Dandenong | 0:4 | ||||||
| Saturday, 06/09/1980 | Keysborough - Werribee City | 3:0 |
| P | Team | P | W | D | L | Diff. | Goals | Pts. | Home | Away | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | Werribee City | 22 | 16 | 2 | 4 | 31 | 50 | : | 19 | 34 | 11 | 9 | 0 | 2 | 27 | : | 9 | 18 | 11 | 7 | 2 | 2 | 23 | : | 10 | 16 |
| 2. | Corio | 22 | 13 | 4 | 5 | 18 | 37 | : | 19 | 30 | 11 | 6 | 3 | 2 | 18 | : | 9 | 15 | 11 | 7 | 1 | 3 | 19 | : | 10 | 15 |
| 3. | Mornington | 22 | 12 | 5 | 5 | 20 | 39 | : | 19 | 29 | 11 | 8 | 1 | 2 | 18 | : | 6 | 17 | 11 | 4 | 4 | 3 | 21 | : | 13 | 12 |
| 4. | Brighton | 22 | 10 | 6 | 6 | 10 | 45 | : | 35 | 26 | 11 | 6 | 4 | 1 | 26 | : | 16 | 16 | 11 | 4 | 2 | 5 | 19 | : | 19 | 10 |
| 5. | North Dandenong | 22 | 6 | 12 | 4 | 6 | 34 | : | 28 | 24 | 11 | 4 | 7 | 0 | 20 | : | 9 | 15 | 11 | 2 | 5 | 4 | 14 | : | 19 | 9 |
| 6. | Nunawading City | 22 | 9 | 4 | 9 | 7 | 41 | : | 34 | 22 | 11 | 5 | 1 | 5 | 22 | : | 18 | 11 | 11 | 4 | 3 | 4 | 19 | : | 16 | 11 |
| 7. | Monash University | 22 | 10 | 2 | 10 | -1 | 35 | : | 36 | 22 | 11 | 6 | 1 | 4 | 20 | : | 15 | 13 | 11 | 4 | 1 | 6 | 15 | : | 21 | 9 |
| 8. | Moorabbin City | 22 | 7 | 7 | 8 | -12 | 33 | : | 45 | 21 | 11 | 5 | 4 | 2 | 22 | : | 17 | 14 | 11 | 2 | 3 | 6 | 11 | : | 28 | 7 |
| 9. | Keysborough | 22 | 7 | 6 | 9 | -5 | 22 | : | 27 | 20 | 11 | 4 | 2 | 5 | 13 | : | 15 | 10 | 11 | 3 | 4 | 4 | 9 | : | 12 | 10 |
| 10. | Sandringham City | 22 | 8 | 4 | 10 | -7 | 33 | : | 40 | 20 | 11 | 3 | 2 | 6 | 15 | : | 22 | 8 | 11 | 5 | 2 | 4 | 18 | : | 18 | 12 |
| 11. | Mooroolbark | 22 | 4 | 4 | 14 | -19 | 24 | : | 43 | 12 | 11 | 2 | 2 | 7 | 13 | : | 22 | 6 | 11 | 2 | 2 | 7 | 11 | : | 21 | 6 |
| 12. | Caulfield City | 22 | 1 | 2 | 19 | -48 | 9 | : | 57 | 4 | 11 | 0 | 2 | 9 | 4 | : | 26 | 2 | 11 | 1 | 0 | 10 | 5 | : | 31 | 2 |
|
Werribee City and Corio are promoted to Metropolitan League Division Three Mooroolbark and Caulfield City are relegated to Provisional League Division One |